Emitter-Active Shell in NaYF₄:Yb,Er/NaYF₄:Er Upconversion Nanoparticles for Enhanced Energy Transfer in Photodynamic Therapy

To realize the potential of near-infrared (NIR) upconversion nanosensitizers for photodynamic therapy cancer, luminescence and energy transfer (ET) efficiency from emitter donors to photosensitizer acceptors need be improved. In current work, nanoparticles (UCNPs) with a core/emitter-active shell structure were constructed enhance not only emission but also ET surface-anchored photosensitizers. The was doped into bridge migration upconverted surface. NaYF4:Yb,Er/NaYF4:Er UCNPs rose bengal (RB) employed as an example. lifted by up ∼81 times core counterpart. effect emitter-doped obvious nanophotosensitizer. RB ∼36 that endow photosensitizers most efficient reactive oxygen species production capability under NIR irradiation. vitro tests on glioma cells conducted validate efficacy NaYF4:Yb,Er/NaYF4:Er/RB agent. Therefore, this work can facilitate development ET-based nanosystems.